Cutting edge: the membrane attack complex of complement is required for the development of murine experimental cerebral malaria.

Cutting edge: the NLRP3 inflammasome links complement-mediated inflammation and IL-1β release.

The complement system is a potent component of the innate immune response, promoting inflammation and orchestrating defense against pathogens. However, dysregulation of complement is critical to several autoimmune and inflammatory syndromes. Elevated expression of the proinflammatory cytokine IL-1β is often linked to such diseases. In this study, we reveal the mechanistic link between complemen...

Experimental Study of the Effect of Laser-Cutting Process Parameters on Heat Distribution and Cutting Edge Quality of Steel Sheets

This study aimed to evaluate Laser-cutting process of Mild Steel St37 sheets with two different thicknesses. In order to evaluate the quality of cutting edge and the depth of the area affected by the heat, several tests were conducted to determine the effect of parameters such as Laser power, Laser beam movement speed and pressure of axillary gas on the quality of cutting edge and the depth of ...

Cutting edge: murine CD59a modulates antiviral CD4+ T cell activity in a complement-independent manner.

CD59 blocks formation of the membrane attack complex of complement by inhibiting binding of C9 to the C5b-8 complex. To investigate a role for CD59 in promoting T cell responses, we compared T cell activation in CD59a-deficient (Cd59a-/-) and wild-type (WT) mice after in vitro stimulation and after infection with rVV. Virus-specific CD4+ T cell responses were significantly enhanced in Cd59a-/- ...

Induction of Experimental Cerebral Malaria Are the Critical APC Required for the Cutting Edge: Conventional Dendritic Cells

An Instantaneous Rigid Force Model For 3-Axis Ball-End Milling Of Sculptured Surfaces

An instantaneous rigid force model for prediction of cutting forces in ball-end milling of  sculptured surfaces is presented in this paper. A commercially available geometric engine is used to represent the cutting edge, cutter and updated part geometries. The cutter used in this work is an insert type ball-end mill. Intersecting an inclined plane with the cutter ball nose generates the cutting...